The GK rat beta-cell: A prototype for the diseased human beta-cell in type 2 diabetes?
نویسندگان
چکیده
منابع مشابه
Type 2 Diabetes and the Aging Pancreatic Beta Cell
The incidence of and susceptibility to Type 2 diabetes increases with age, but the underlying mechanism(s) within beta cells that contribute to this increased susceptibility have not been fully elucidated. Here we review how aging affects the proliferative and regenerative capacity of beta cells and how this impacts beta cell mass. In addition we review changes that occur in beta cell function ...
متن کاملType 2 Diabetes Mellitus: beyond the Beta Cell
1. Department of Medicine IV, Tübingen University Hospital, Tübingen, Germany 2. Royal Liverpool University Hospital, Liverpool, UK; AstraZeneca, Luton, UK 3. Department of Endocrinology, University Hospital of Leuven, Leuven, Belgium 4. Division of Diabetology, St. Josef-Hospital, Ruhr-University, Bochum, Germany 5. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denma...
متن کاملBeta-cell replacement for type I diabetes.
The ability to achieve insulin independence with either solid-organ pancreas or islet transplantation has increased the number of patients seeking beta-cell replacement as an alternative to insulin therapy. Despite dramatic improvements in the ability to achieve insulin independence following solid-organ pancreas transplantation, the secondary complications of long-standing diabetes are frequen...
متن کاملBeta-Cell Function and Failure in Type 2 Diabetes
The main role of beta-cell is to synthesize and secrete insulin in order to maintain circulating glucose levels within physiological range. Although there exist several triggers of insulin secretion like nutrients (amino acids such as leucine, glutamine in combination with leucine, nonesterified fatty acid), hormones, neurotransmitters and drugs (sulfonylurea, glinides), glucose represents the ...
متن کاملBeta-cell function and mass in type 2 diabetes.
The aim of the work described here was to improve our understanding of beta-cell function (BCF) and beta-cell mass (BCM) and their relationship in vivo using the minipig as a model for some of the aspects of human type 2 diabetes (T2DM). More specifically, the aim was to evaluate the following questions: How is BCF, especially high frequency pulsatile insulin secretion, affected by a primary re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2009
ISSN: 0303-7207
DOI: 10.1016/j.mce.2008.06.013